Nuclear Magnetic Resonance Spectroscopist

Scientist


None


Ability to Obtain Public Trust



We are looking for a Nuclear Magnetic Resonance (NMR) Spectroscopist to support the Analytical Chemistry Core (ACC), Division of Preclinical Innovation (DPI) at NCATS. This position is a full-time role located in Rockville, MD.

• Provide support for the ACC NMR Spectroscopy laboratory, including operation of four (4) 400 MHz and one (1) 600 MHz NMR spectrometers.
• Conduct advanced NMR experiments and analyses, including 1D, 2D, nD, and VT NMR for structure verification, conformational analysis, impurity profiling, and purity assessments.
• Assess, design, and optimize chemical methods and experiments, modifying procedures to address challenges and improve performance.
• Develop and implement novel NMR methodologies and workflows, including automation and high-throughput platforms for small molecules, peptides, and proteins.
• Provide technical training and mentorship to staff on NMR instrumentation, laboratory procedures, and analytical techniques.
• Operate, maintain, and troubleshoot high-field NMR instruments; perform instrument QC and routine servicing.
• Perform sample preparation and execute specialized techniques such as STD, HDX, RDC, relaxation analysis, and binding studies.
• Analyze and interpret spectral data; generate reports, figures, and scientific documentation.
• Conduct literature reviews and contribute to manuscripts, abstracts, and presentations.
• Maintain compound tracking systems and ensure proper documentation and data integrity.
• Monitor laboratory safety practices and ensure compliance with established protocols.
• Perform weekly liquid nitrogen fills and quarterly helium fills.
• Collaborate with internal and external stakeholders on translational research projects.
• Present updates and findings to laboratory teams on a regular basis.
• Incumbent capture, no other candidates were considered due to incumbent candidate identified. They meet the labor category requirements provided by the customer.

• Master's degree in Chemistry, Biochemistry, Biophysics, or a related discipline.

• Minimum of three (3) years of experience in NMR spectroscopy or analytical chemistry laboratory environments.
• Demonstrated experience operating NMR spectrometers (Bruker, JEOL, Agilent, or similar platforms).
• Proficiency with NMR acquisition software (TopSpin, Delta, VnmrJ) and data processing tools (Mnova, ACD/Labs, nmrPipe, XPLOR-NIH).
• Experience performing advanced NMR techniques including STD, HDX, RDC, and relaxation studies.
• Ability to manage multiple projects and priorities simultaneously.
• Proficiency in Microsoft Office (Excel, Word, Outlook, PowerPoint).
• Ability to work collaboratively in a research laboratory setting.
• Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

• Ph.D. in Chemistry, Biophysics, or a related scientific discipline.
• Strong analytical, organizational, and time management skills.
• Effective written and verbal communication skills.
• Experience with fragment screening and protein sample preparation.
• Knowledge of automation systems and high-throughput screening technologies.
• Familiarity with computational and visualization tools such as ChemDraw, PyMOL, GraphPad Prism, and MOE.
• Programming experience in Python or R.
• Prior experience supporting translational or biomedical research programs.
• Experience writing manuscripts for peer-reviewed journals.

The annual salary range for this position is $74,000.00-$124,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.



Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance
• Personal and Family Sick Time & Company Paid Holidays
• Parental Leave
• 401(k) Retirement Plan
• Group Term Life and Travel Assistance
• Voluntary Life and AD&D Insurance
• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
• Transit and Parking Commuter Benefits
• Short-Term & Long-Term Disability
• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
• Employee Referral Program
• Corporate Sponsored Events & Community Outreach
• Care.com annual membership
• Employee Assistance Program
• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
• Position may be eligible for a discretionary variable incentive bonus

Guidehouse is an Equal Opportunity Employer-Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com . All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

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