Scientist (Cell Culture - Biopharmaceutical)

Piper Companies is seeking a skilled Scientist (Cell Culture/Upstream) to support MS&T, process development, scale-up, and technology transfer of biopharmaceutical manufacturing processes for a well-established biopharmaceutical organization out of Frederick, MD.

Responsibilities of the Scientist:

· Provide technical support for upstream manufacturing operations

· Lead upstream operation activities including operating bioreactors (stainless steel, single-use) for cell growth, aseptic technique in BSCs for inoculation/sampling, and cell culture operations (harvest, maintaining, thawing, etc.)

· Analyze process data to identify trends, deviations, and opportunities for improvement

· Lead CAPA investigations

· Support or lead techn transfer activities for clinical manufacturing operations

· Participate in process scale-up studies

· Prepare technical reports, presentations, and documentation for internal and regulatory use

Qualifications of the Scientist:

· 4+ years of experience with cell culture and upstream process development activities

· Post Doctoral experience (western blots, cell culture, flow cytometry, bioreactors, tissue engineering, biomedical engineering experience preferred)

· Understanding of biologics manufacturing processes including mammalian cell culture, purification, formulation scale up processes

· Experience with monoclonal antibodies and cell/gene therapies preferred

· Tech transfer across manufacturing sites would be ideal experience for candidate

· PhD (Doctor of Philosophy) degree in life science related field required

Compensation of the Scientist:

· Salary: Between $80,000 - $115,000 based on years of relevant experience

· Comprehensive Benefits: Medical, Dental, Vision, 401K, PTO (Paid Time Off), Paid Holidays, Sick Leave as required by law

This job opens for applications on 1/15/2026. Applications for this job will be accepted for at least 30 days from the posting date

Keywords:

Manufacturing, biopharmaceutical, MS&T, manufacturing science and technology, manufacturing science & technology, bioprocessing, upstream, downstream, cell culture, fermentation, mammalian, scale up, scale-up, protein purification, chromatography, filtration, process development, process scale-up, process optimization, process characterization, validation, PPQ, CPV, tech transfer, analytical method development, method development, analytical, formulation development, PAT, process analytical technology, qbd, quality by design, aseptic processing, laboratory, GMP, good manufacturing practice, biotechnology, biotech, single-use, bioreactor, CAPA, deviation, QA, quality assurance, ICH, FDA, EMA, change control, corrective and preventative actions, batch record, IND, BLA, NDA, regulatory, technical writing, LIMS, laboratory information management system, Python, TFF, tangential flow filtration, depth filtration, filtration, centrifugation, affinity, ion exchange, harvesting, ultrafiltration, diafiltration, UF/DF, viral clearance, column packing, scale-down modeling, HPLC, SDS-page, ELISA, DOE, design of experiment, CHO, microbial fermentation, HEK293, media preparation, single-use, stainless steel, seed train, pH, nutrient feeding, CPP, critical process parameter, CQA, critical quality attributes, GLP, good laboratory practice, manufacturing specialist, manufacturing associate, bioprocess associate, process development associate

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